POWERHOUSE has 30+ years turbocharging both street and track bikes. Turbo bikes - built and tuned properly - are rock-solid reliable. Make sure that your motor is built to withstand more power than you plan on putting down; build your foundation strong and solid. That is key. Get a good, trusted and reliable kit - like the RCC - and have it installed and tuned by someone who knows what they are doing. If you set it up to run on pump gas, run it that way. Make sure that when it is tuned, it is done using the same fuel you intend on using, and make sure that the A/F is checked and set up properly for every boost level you intend on running: low boost, high boost, and everything in between. Don't "cheap out" on anything - do rods, pistons, studs, valves (Gen 2), valve springs, oil pump gear, good clutch springs and slave support. Build it right, build it once!
I have been building, tuning and riding turbo bikes since 1978. I have always had at least one turbo street bike in my stable. I went cross country, from N.Y. to Salt Lake City, Utah - on a turbo bike. Through snow, rain, and all kinds of miserable weather. I went from N.Y. to Montreal, non-stop, on a turbo bike, and then back again. I have put countless miles on turbo street bikes, and would not think twice about taking one on a long trip. I have three turbo street bikes right now- one of them is an RCC Ultra that put down just over 600 hp. Weather permitting, I ride that bike every day, and have been everywhere on that bike. I commute with it, and do a lot of sport riding with it. I've raced many other bikes, and many turbo cars with it. I've had it WFO more times than I can count. Right now this bike has over 7,000 street miles on it since the build. The only maintenance involved is changing the oil - although I have to admit, I've had to change the rear tire twice because of how I ride.
My opinion is that it is just as reliable as a stock Busa, because it was built right, and tuned right. Its just not as boring as a stock Busa!