I have 16/42 and combined with stock speedometer error, I had to adjust my speedohealer to -16.5% to make my speedo dead on @ 50 MPH.
A friendly deputy sheriff was nice enough to run a few tests using his laser gun to verify my speeds.
Even with stock gearing and speedo, Busa's are typically off 3-4 MPH @ 50. They read 6-8% faster than you are actually going.