I lived in Greenville for about 10 years. You should expect very nice (probably highs in the 80s and lows in the high 50s or so) weather, and many, many Baptists. Actually, Let me take that back - I have no problem with Baptists as a denomination, but what you have there are Bob Jones students. If you're downtown (which I recommend going to see) on the weekend, you can expect some of the students to be down there either preaching or telling you that you're going to hell.
There are lots of really fun things to do in Greenville that are a lot of fun. PM me and I'll be happy to give you some suggestions on what to do.
You MUST ride up to the top of Caesar's Head though, as well as Table Rock. You get there by taking 25 north up through Traveler's Rest and follow the signs. Driving up Caesars head is like riding a mini Dragon, except with a 9% average grade.