We have run the combo on cars, bikes, sand rails, drag boats and diesel trucks.. setup correctly you can do this.
Biggest problem? underbuilt motor...
guys forget that you need a connecting rod/block/head combo that can take the power.. (tend to go boom otherwise) also if you are off on the tune up? well bad things happen.. break an intake valve spring or float a valve..and you have a bomb... (and a big one)
as far as the cryo cooling goes, we never did that.. and I am surprised that it is allowed considering the "enviro heads" that are running around now days..