It is my understanding that a larger and heavier rotor would have an impact on MOI (moment of inertia), causing a slower turn in and decreased agility, by adding rotational wheel mass. This is assuming that all other factors remain equal.
However, for the radial mounted calipers found on newer sport bikes, this wouldn't be an issue. As their front rotors are generally no larger than is typical of conventional set ups. Or if they are larger in diameter, it is only by a few millimeters and the rotors are made thinner or given wave cuts to negate the effect on mass.
Now the Buell rotors are another matter. They are large and heavy. However there is only one of them, so I am guessing they aren't much heavier than a conventional twin rotor system. But, they carry their weight farther out away from the axis of rotation. So, in theory they would add more MOI than a conventional twin rotor of the same mass. Buell claims that they have made the front wheel lighter though, so we might be back to square one. I honestly don't know.
I suspect that the Buell system is no better than the conventional sport bike brakes of the past five years or so. Both in terms of resistance to fade and effect on MOI. With the right pads, they probably could have good initial bite and feedback. But I doubt they are as good as the new brakes found on current sport bikes (both conventionally mounted calipers and radial mounted calipers.) But I honestly don't know what effect, if any, these brakes have on the total MOI of the Buells or their agility.