I rode Skyline Drive last July. With an enforced 35 MPH speed limit the ride wasn't about cornering....it was just flat out beautiful. Lucky thing for the slow pace because a large black bear ran in front of me. Any faster and I would have hit it, and then it would have killed me.
I went on a Tuesday morning, so traffic wasn't too bad at the start. But by the afternoon I was getting behind slow moving campers and trucks, and I mean really slow moving. With the twisties it was difficult finding a place to pass, even double yellow passing. As such I wouldn't recommend going on weekends.