oh yea..
takes spark, fuel and compression to make a motor run.. should always start with basics first.. tearing stuff apart and fixing it without can cause more trouble..
You can go from 1 issue to 2 without even realizing it..
I generally spin a motor over and listen to it.. Many can hear a low cylinder (or multiple) instantly.. from there I usually shoot a bit of carb clean down the intake and see if it tickles the motor.. (In your case you would give a shot down each velocity stack and see if it picks up the cylinder momentarily..)
if the motor "sounds" physically ok and the carb clean does not do anything, it would be time to check spark.. if that appears ok? time to get bit more physical and do a compression check..
when it is two adjoining cylinders? I would be a bit more worried..