I used to drive OTR for TMC(largest privately owned flatbed company)they are excellent to work for. You'll make as much or more than the average 2500 to 3000 mile per week company, and drive about half the miles. You'll also be home every weekend if you choose. The downside is the work that comes with flatbedding. A full trailer needs 2 tarps(when required) and they weigh 80 lbs each. It's also alot of work just securing most loads, and of course in all weather.
Even if you drive for a van trailer company you still have the ongoing headache of ever increasing traffic, and waiting to pick up and drop off loads. Some areas of the country are obviously alot worse to drive in than others too.
Worst part is having a great week, being well ahead of schedule on Friday morning, excited to get home, and then running into one or more traffic jams from rush hour's and accidents and getting home the next day.
Pros and cons to it, I got a local job a few years ago because I was tired of running and I just wanted to be at home with my wife(and now daughter, I can't imagine being away from her all the time). Home every weekend is the best driving deal out there for a OTR family man, but by the time you do what needs to be done, relax and settle down, it's time to go again(48hrs flys by). Your wife/kids will also want to go places with you when you're home, and you'll probably find that after driving all week, all you want to do is sit home. That can cause stress even when both sides fully understand why.
Personally, unless you're just passionate and born to be a trucker, it gets old. If you're a family man, you'll miss being able to be home, especially when your family really needs you and you're two days away.
Some days I'de love to drive a truck cross country again(there is alot of great things about the job too), but that would give me my fix for a year or so. I'm glad I did it, absoloutely no regrets, but I'm happy at home. Think long and hard man, and good luck with whatever you do.