I also spent a lot of money trying to lose some Busa fat. Ti bolts, GP4 calipers, Ohlins suspension, lighter rear sets, etc. Basically, the most impact comes from wheels. I went with the Cormoto aluminum and they made a huge difference. So much so I was sort of wishing I had gone Carbom fiber but I still don't trust them on such a heavy, powerful bike. I was super excited when my busa weighed in at 501 lbs with fuel. I later found out that was a very tilted scale and the real weight is 535-555.
That's a lot of weight still, but my BWM weighs 550, and it feels lighter and much more nimble than the Busa. That's when I realized its not the ultimate weight as much as where the weight is. The further the weight is away from the CG of the bike the more it restricts direction changes. But more than that, the gyroscopic effect of the spinning crankshaft impacts the bike's roll rate. That inline crank with big 1250cc pistons is very stable as the rpm's rise. The BMW's crank is axial on the bike (front to back vs side to side). That means it loves to roll.
So, the bottom line on weight is pretty simple: The cheapest and most impactful way to improve your Busa's performance is to lose some Busa rider weight. You are the heaviest thing on the bike and the farthest away from the CG of the bike.
BTW: The Busa's somewhat slow handling is as much due to its geometry as its weight. It is designed to be stable for a novice at 180 mph. Consequently, making the beast do what you want can only be done with counter steering (not titanium). Ride her correctly and she is very capable.